MAOIs act by inhibiting monoamine oxidase, a complex enzyme system that metabolizes excess serotonin and epinephrine. It holds the negativity of inducing potential life-threatening problems and therefore cannot be used in patients with congestive cardiac failure or in those with a history of liver disease. It can be dangerous for those who are hypersensitive to its ingredients. It should be used only when other available Antidepressant medications fail as treatment options for depression.
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